Clinical Research

The clinical researchers at John Theurer Cancer Center at Hackensack University Medical Center have played a critical role in the development of many of the prominent anticancer drugs used in oncology. Today, we are conducting more than 350 clinical trials—more than any other cancer center in New Jersey. Our physicians and nurses screen every patient for clinical trial eligibility and enroll more than 1,000 patients each year in these pivotal research studies.

Through our unique collaborations with industry sponsors—including large pharmaceutical companies headquartered in New Jersey—we offer studies of novel agents that are not available elsewhere, from promising targeted therapies to immunotherapies. You can receive the latest evidence-based treatments closer to where you live and work, across the entire Hackensack University Medical Center network.

A Dedicated Research Team

In addition to the physicians who care for you, our clinical research team includes more than 100 staff members dedicated just to the research program, including research nurses, data coordinators, research finance professionals, and other healthcare professionals. We recognize and appreciate the value of each and every patient who participates in our research studies, and we work together to ensure that your experience during your enrollment in a clinical trial is as positive and rewarding as it can be.

A Special Program for Phase I Clinical Trials

Phase I studies are the first step of evaluation of a new drug in patients. Our program offers you the earliest access to promising new anticancer therapies. John Theurer Cancer Center has the highest number of early-phase clinical trials in New Jersey. Our dedicated Phase I Clinical Trials Program enables you to receive innovative therapies, including novel combinations, at the earliest stage of development.

Innovations in the Treatment of Amyloidosis Suzanne Lentzsch M.D., PhD


Suzanne Lentzsch how John Theurer Cancer Center is innovating the treatment of patients with amyloidosis by taking a dual approach.

Changing the Future of Cancer through Collaboration

Through our partnership with the National Cancer Institute’s Immunology branch, Georgetown University’s Lombardi Comprehensive Cancer Center, the Parker Institute for Cancer Immunotherapy, and Memorial Sloan Kettering, we are propelling advances in novel anticancer treatments, including immunotherapy and cellular therapies. Progress in the development, assessment, and FDA approval of these treatments is happening at an accelerating pace, and you may be able to benefit from these innovative therapies right here at John Theurer Cancer Center.

A Commitment to Translational Research

Translational research (“bench-to-bedside”) efforts promote the extension of new developments from basic science research laboratories to the clinic, where they may help patients. In our David Joseph Jurist Center for Research and through our affiliations with Georgetown’s Lombardi Cancer Center, the Stevens Institute of Technology in New Jersey, and Memorial Sloan Kettering, we are dedicated to translational research. Our scientists are studying epigenetic factors that affect various cancers, novel approaches to improve outcomes following hematopoietic stem cell transplantation, and how immunotherapy can be influenced by immune cells and the microbiome. We are also opening a comprehensive translational science center and a new medical school in collaboration with Seton Hall University, in Nutley, New Jersey, at the former location of Hoffmann-La Roche.

Embracing Precision Medicine

Through our partnership with Memorial Sloan Kettering, we are using precision medicine to tailor the optimal type and sequence of treatment for each of our patients. Our combined clinical experience and resources will allow us to implement precision medicine in ways that benefit patients today and in the future.

COTA


Implementing Value-Based Care with Big Data

COTA (Cancer Outcomes Tracking and Analysis) is an initiative using “big data” to identify the best way to treat patients with similar disease characteristics. By precisely classifying our patients at the time of diagnosis and by implementing real-time analytical methods to interpret the data we collect, we are empowering cancer professionals with high-quality research data, creating alternative healthcare payment models, creating national benchmarks for patient outcomes, accelerating drug discovery and approval, and helping patients make informed decisions about their own care. COTA has the power to improve clinical outcomes for each patient. By optimizing treatment decision-making, we can also reduce cancer care costs along the way.

Pivotal Resources for Cancer Research

Two vital resources used by researchers at John Theurer Cancer Center are the Tumor Registry and Tissue Repository. The Tumor Registry (also called the Cancer Registry) is a source of data on all reportable tumors that are diagnosed and/or treated at our facility. The Tumor Registry is staffed by certified tumor registrars (CTR) and data management experts. They interpret and collect a wide range of demographic, diagnostic, treatment, and follow-up information on each patient.

They submit these data, as required, to state and national registries for use in research, treatment, and prevention initiatives that have the potential to benefit patients everywhere. Our physicians, researchers, and healthcare administrators rely on these data to identify cancer trends, observe how the disease presents in different populations, measure outcomes, and formulate plans to continuously improve patient care.

Our Tissue and Tumor Bank is a rich source of tissue, blood, and bone marrow samples from patients who gave their consent after undergoing biopsies, surgery, or other cancer-related procedures at John Theurer Cancer Center. Our scientists use these samples to analyze and study multiple types of cancer to learn more about how cancer develops, to develop innovative new treatments, and to predict how well a treatment can work.

Clinical Trials Database


Please check our clinical trials database regularly, as the information is frequently updated.

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